"Supralimus" |
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The delivery vehicle used in Supralimus™
is biodegradable / biocompatible polymers that fulfil pharmacological, pharmacokinetic, and mechanical requirements. The release
of the drug into the vessel take place in a manner that is consistent with the drug's mode of action. Drug release is predictable
and in a controlled concentration and time. The delivery vehicle is suitable for sterilization and follows the geometric change
of configuration during stent expansion and resists mechanical injury caused by the inflation of the balloon.
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Insignificant action against fibrinogen content in the plasma |
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Although the pre-drug sirolimus (SRL) binds to
FKBP-12, the complex that is formed between SRL and FKBP binds to the mammalian target of rapamycin (mTOR). The SRL-FKBP-mTOR
complex inhibits biochemical pathways that are required for cell progression through the late G1 phase or entry into the S
phase of the cell cycle. Thus, unlike cyclosporine (CsA), SRL blocks cytokine signal transduction. SRL is thought to target:
(1)The 70-kD S6 protein kinase p70S6K Sirolimus-Eluting Coronary Stent |
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